A 22-year-old male presented with fever and increasing dyspnea. On features suggestive of acute bronchitis and respiratory distress were seen. He gave history of frequent episodes of haemoptysis, sinusitis, pneumothorax and fatty stools in the past for which he has been hospitalized in multiple times. RFTs and LFTs were deranged USG abdomen -cirrhotic changes in the liver and multiple renal calculi X-ray chest- signs of necrotizing pneumonia Sputum culture- non fermenting colonies which were mucoid and oxidase positive seen Which of the following drug can be used to treat the above organism: -
High-Yield Explanation
This is a case of cystic fibrosis in an adult presenting with Pseudomonas /Burkholderia infection. These bugs are known to be resistant to commonly used antimicrobials due their tendency to form biofilms. Thus a combination of drugs inhaled plus IV is likely to give better response. CYSTIC FIBROSIS Autosomal recessive Disease of exocrine gland Adult with CF presents with recurrent chest infections, sinusitis, pancreatitis and persistent cough Sweat chloride test is performed (value >60 mmol/L = consistent with CF) Due to mutation of CFTR gene on Chromosome 7.