Bremelanotide is used for:

Ans. a. Erectile dysfunction (Ref: Salvage of Sildenafil Failures with Bremelanotide: A randomized, double blind, placebo controlled study: The Journal of Urology 2008:179:1066-1071)Bremelanotide is used for erectile dysfunction."In studies, bremelanotide was effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder)."BremelanotideBremelanotide was developed from the peptide Melanotan II which underwent testing as a sunless tanning agent.It functions by activating the melanocortin receptors MC1R and MC4R, to modulate inflammation and limiting ischemia.In initial testing, Melantoan II did induce tanning but additionally a used sexual arousal and spontaneous erections as unexpected side effects.In studies, bremelanatide was effective in treating sexual dysfunctionQ in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).Unlike sildenafil and other related mediations, it does not act upon the vascular system, but directly increases sexual desire via the nervous systemQHowever, the trial was discontinued after concerns were raised over adverse side effects of increased blood pressure.Recently, it is being tried in hemorrhagic shock and reperfusion injury.