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Pathology Immunity da77c3ec

Which Antibody crosses placenta?

A
IgG1
B
IgG4
C
IgA
D
IgD
High-Yield Explanation
Ans. (a) IgG1(Ref: Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective; pg 484)All four IgG subclasses cross, although the IgG1 and IgG3 subclasses are predominate.IgG1 crosses earliest in pregnancy & is the primary immunoglobulin transferred before 28 weeks.IgG3 crosses later & does not reach maternal levels until after 32-33 weeks

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