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Pharmacology General da60995e

All of the following statements about nateglinide are true except ?

A
Decreases postprandial hyperglycemia
B
Hypoglycemia is less common than with sulfonylureas
C
It decreases insulin resistance
D
It acts by releasing insulin
High-Yield Explanation
Sulfonylureas, nateglinide and repaglinide act by inhibiting ATP sensitive K channels and thus resulting in the release of insulin. Like insulin, all of these drugs can cause hypoglycemia. However, nateglinide therapy produces fewer episodes of hypoglycemia as compared to other oral insulin secretagogue. Nateglinide and repaglinide are short-acting and thus can reduce post-prandial hyperglycemia.

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