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Pharmacology General d9c19096

Inhibits mitosis by forming microtubules -

A
Vinca alkaloids
B
Docetaxel
C
Etoposide
D
Colchicine
High-Yield Explanation
Ans. is 'b' i.e., Docetaxel Taxanes (Paclitaxel and Docetaxel) enhances polymerization of tubulin (a mechanism opposite to that of vinca alkaloids) --> the microtubules are stabilized and their depolymerization is prevented. Vinca alkaloids (vincristine, vinblastine) prevent polymerization and assembly of microtubules.

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