Atheromatous changes of blood vessels affects early which of the following organ?

Large elastic aeries (e.g., aoa, carotid, and iliac aeries) and large and medium-sized muscular aeries (e.g., coronary, renal, and popliteal aeries) are the vessels most commonly involved by atherosclerosis. Accordingly, atherosclerosis is most likely to present with signs and symptoms related to ischemia in the hea, brain, kidneys, and lower extremities. Myocardial infarction (hea attack), cerebral infarction (stroke), aoic aneurysms, and peripheral vascular disease (gangrene of extremities) are the major clinical consequences of atherosclerosis. ( Robbins Basic Pathology, 9 th edition, page 342 )