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Biochemistry General d8deae3b

Arsenic inhibits all except :

A
PDH
B
Lipoic acid
C
a-KG dehydrogenase
D
Enolase
High-Yield Explanation
D i.e. EnolaseArsenite (trivalent form of arsenic) forms a stable complex with thiol (-SH) group of lipoic acid, making it unavailable to serve as a coenzyme. So arsenic poisoning is primarily d/t inhibition of enzymes that require lipoic acid (lipoate) as a coenzyme including E2 of PDH complex, a-Ketoglutarate dehydrogenase and branched chain a-ketoacid dehydrogenaseQ.

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