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Medicine Infection d8a366e1

Zidovudine toxicity is increased by all except -

A
Azithromycin
B
Probenecid
C
Cisplatin
D
Paracetamol
High-Yield Explanation
Paracetamol increases zidovudine toxicity ,probably by competing for glucuronidation. Azole antifungals also inhibit AZT metabolism. Other nephrotoxic & myelosuppressive drugs & probenecid enhance toxicity . Reference :Tripathi textbook of pharmacology 7th edition pg no 807.

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