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Anaesthesia General d7d7314e

Which of the following local anaesthetic is the shoest acting which aids in obstetric anaesthesia?

A
Tetracaine
B
Bupivacaine
C
Prilocaine
D
Chloroprocaine
High-Yield Explanation
Chloroprocaine is a chlorinated derivative of procaine. Its major assets are its rapid onset and sho duration of action and its reduced acute toxicity due to its rapid metabolism (plasma t1/2 ~25 seconds). Chloroprocaine gained widespread use as an epidural agent in obstetric anesthesia, where its rapid hydrolysis served to minimize risk of systemic toxicity or fetal exposure. Ref: Catterall W.A., Mackie K. (2011). Chapter 20. Local Anesthetics. In B.C. Knollmann (Ed), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.

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