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Medicine Fluid and electrolytes d705697d

Sweat chloride levels are Increased in all of the following conditions except -

A
Cystic fibrosis
B
G-6 PD -deficiency
C
Heriditary nephrogenic-diabetes incipidus
D
Obesity
High-Yield Explanation
cystic fibrosis, the CFTR chloride channel is defective, and does not allow chloride to be reabsorbed into sweat duct cells. Consequently, more sodium stays in the duct, and more chloride remains in the sweat. The concentration of chloride in sweat is therefore elevated in individuals with cystic fibrosis They are also increased in G6pd deficiency, hereditary nephrogenic diabetes insipidus Ref Davidson 23rd edition pg 351

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