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Pathology General d6f5cf46

Translocation seen in Ewing's sarcoma is:

A
t(8,11)
B
t(11,22)
C
t(11,18)
D
t(14,18)
High-Yield Explanation
Ans: B. t(11,22)Genetic exchange between chromosomes can cause cells to become cancerous. Most cases of Ewing's sarcoma (85%) are the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11. Other translocations are at t(21;22) and t(7;22).

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