All of the following factors tend to increase the volume of distribution of a drug EXCEPT:

- Factors affecting drug distribution    Lipid solubility - Higher the solubility, higher the distribution    Ionization at physiological pH - Higher the ionization, lower the distribution    Degree of plasma protein binding - More the binding, less the distribution    Affinity for different tissues - Higher affinity, higher distribution    Regional blood flow - More the flow, more the distribution    Fat: lean body mass ratio (changes with age) - Increases with age     Disease like CHF, uremia, cirrhosis