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Pharmacology General d618b095

Which one of the following drugs does not have active metabolite ?

A
Diazepam
B
Propranolol
C
Allopurinol
D
Lisinopril
High-Yield Explanation
- Among the given options, only Lisinopril does not have an active metabolite. Except for Captopril and Lisinopril, all Angiotensin Converting Enzyme (ACE) inhibitors are prodrugs. - Diazepam produces Oxazepam and many other active metabolites. - Propranolol can give rise to 4-hydroxyPropranolol which has β antagonist activity - Oxypurinol is produced from Allopurinol.

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