The drug of choice in treatment of inflantile spasms is

Infantile spasms:- West syndrome Onset : 3-8 months of life Characterised by combination of salaam spells( sudden dropping of the head and flexion of arms), developmental retardation, hypsarrythmia on ECG. Causes- Hypoxic ischemic encephalopathy Neurocutaneous syndromes Perinatal infections Hemorrhage Injury Metabolic disorders Localized structural malformations  The spasms occur in clusters usually on waking Drug therapy- Intramuscular ACTH 40-60 unit per day may be given 4-6 weeks and tgen tapered off. On the other hand oral prednisolone at 2 mg/ kg / day in divided doses may also be used. These agents abolish spasms and may result in resolution of hypsarrythmia.