The antibiotic of choice in acute epiglottitis pending culture sensitivity repo is:

Ampicillin or third generation cephalosporin are effective against H. influenzae and are given by parenteral route. - Dhingra 5/e, p 308 According to Harrison DOC are: Ampicillin + Sulbactam (Not ampicillin alone) Cefuroxime Cefotaxime Ceftriaxone According to Scott's Brown 7/ed vol-2 pg-2251 The antibiotics of choice are second and third generation cephalosporin. Ampicillin was often prescribed but resistant H.influenza are now emerging According to Turner 10/e, p 390 Chloramphenicol is the antibiotic of choice and it should be given intramuscularly or preferably intravenously. Amoxycillin or ampicillin is no longer advised as haemophilus organism are now sufficiently often resistant to make its use inappropirate.