What is the side effect of Phenothiazines

(D) Lens & corneal pigmentation# Phenothiazines, including chlorpromazine and thioridazine, can cause brown pigmentary deposits in the cornea, conjunctiva, and eyelids. The deposits generally are found in Descemet's membrane and the posterior cornea. They typically do not affect vision.> The ocular deposits generally persist after discontinuation of the medication and can even worsen, perhaps because the medication deposits in the skin are slowly released and accumulate in the eye.> Chlorpromazine (Thorazine)> Thorazine has been shown to be associated with pigmented corneal deposits and anterior capsular cataracts. Pigmentary retinopathy is usually associated with a much higher dose (>2400 mg/d).> Pigment deposition on the cornea and lens appears to be dose related and is usually irreversible.> Chlorpromazine-induced anterior cataracts do not normally extend to the rest of the lens even when patients continue taking chlorpromazine.> Usually enjoy good vision for a long period despite a dense cataract at the pupillary region.