Antithyroid drug of choice in pregnancy is :

Ans. is a i.e. Propylthiouracil Management of Hypehyroidism during Pregnancy : Medical management is the management of choice.deg Antithyroid drug of choice is propylthiouracildeg because it : -- Inhibits conversion of T, to -13deg -- Crosses placenta less rapidly than rnethimazoledeg -- It is not associated with aplasia cutis seen with methimazole deg Both propylthiouracil and methimazole / carbimazole are however effective and safedeg Side effect of propyithiouracil : Transient leukopenia, Agranulocytosis and Fetal hypothyroidism Side effect of methimazole/carbimazole : -- Aplasia cutis -- Esophageal atresia -- Choanal atresia Radio active iodine is an absolute contraindication in the treatment of thyrotoxicosis in pregnancy. Infect it should not be given to patients even wanting pregnancy within 1 year. Surgical Management : Thyroidectomy may be carried out after thyrotoxicosis has been brought under medical control.deg Because of increased vascularity of thyroid gland during pregnancy, such surgery is more complicated than in non preg? nant state. It is indicated in women who cannot adhere to medical treatment or in whom drug therapy proves toxic.