Pharmacology C.N.S d435d0ca Which drug has least extrapyramidal symptoms? A Aripiprazole B Loxapine C Fluphenazine D Chlorpromazine High-Yield Explanation (Ref: KDT 8th ed. pg. 467)* Among given choice, least risk of EPS among atypicals is: ARIPIPRAZOLE.* Typicals always has high EPS.