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Biochemistry Enzymes d3c48ee5

Activity of which of the following enzyme increase in alcoholism?

A
Lactate dehydrogenase
B
Acid phosphatase
C
Alkaline phosphatase
D
Gamma-glutamyltransferase
High-Yield Explanation
Ans. d (Gamma-glutamyItransferase). (Ref. Harper's Biochemistry 26th ed. 212)# Increased hepatic gamma-glutamyltransferase (GGT) activity following chronic ethanol consumption has been attributed to enzyme induction, dietary carbohydrate imbalance, and/or to hepatic cell damage.# It is suggested that cellular damage following increased lipid accumulation, depletion of hepatic glutathione, or changes in biliary flow may be associated with the increased GGT activity.

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