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Pediatrics General d3709637

A parent is homozygous and a parent heterozygous for an autosomal recessive gene. What will be the outcome –

A
75% children affected
B
No child affected, but all are carriers
C
50% children affected, rest are carriers
D
25% children affected, rest are carriers
High-Yield Explanation
Autosomal recessive disorders Autosomal recessive disorders are manifested in homozygous state, i.e. when both alleles at a given gene locus are mutant. There may be following five situations -

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