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Medicine Kidney d299c42a

Kimmelstiel-Wilson lesions are characteristically seen in-

A
Systemic lupus erythematosus
B
Amyloidosis
C
Malignant hypeension
D
Diabetic nephropathy
High-Yield Explanation
Diabetic nephropathy - Within 1-2 yrs after onset of clinical diabetes , morphologic changes appear in the kidney. Thickening of GBM is a sensitive indicator for the presence of diabetes . mesangial sclerosis ( accumulation of extracellular matrix in mesangium) is seen . Some patients also develop eosinophilic ,PAS +nodules called kimmelsteil -Wilson nodules . prominent vascular changes are frequently seen with Hyaline and hypeensive aeriosclerosis . Ref:Harrison 20 th edition pg no 2144

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