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Which of the following best explains why Lignocaine has a higher fetal-to-maternal plasma ratio when compared with bupivacaine?

A

Bupivacaine has low molecular weight

B

Lignocaine has higher protein-binding

C

Bupivacaine has a lower dissociation constant (pKa)

D

Lignocaine is less protein bound

High-Yield Explanation

Lignocaine is less protein bound than bupivacaine. Unbound form of drug thus easily gets transferred across placenta.

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