Gynaecology & Obstetrics
Medical, surgical and gynaecological illness complicating pregnancy
d1dd13f9
Mrs. X, Primigravida at 36weeks complains of generalized pruritis with increased intensity in soles. Diagnosis is
High-Yield Explanation
Clinical presentation of Intrahepatic Cholestasis of Pregnancy:Pruritus develops in late pregnancy, although it occasionally manifests earlier. There are no constitutional symptoms, and generalized pruritus shows a predilection for the soles. Skin changes are limited to excoriations from scratching. Biochemical tests may be abnormal at presentation, but pruritusmay precede laboratory findings by several weeks. Approximately 10 percent of women have jaundice.Ref: William&;s Obstetrics; 24th edition; Chapter 55