Female to male ratio of microprolactinomas is?

Pituitary Tumors 1. Eosinophil (Acidophil) adenomas: Tumour is usually small. Rarely it causes compressive features. It secretes excess growth hormone causing acromegaly in adults and gigantism in children. 2. Chromophobe adenomas are common in females and in the age group--20-50 years. Initially, it is intrasellar and after sometime becomes suprasellar. Later, it extends intracranially often massively, causing features of Intracranial space occupying lesion. It presents with myxoedema, amenorrhoea, infeility, headache, visual disturbances, bitemporal hemianopia, blindness, intracranial hypeension, epilepsy. Differential diagnosis: Meningiomas, aneurysms. CT scan, angiogram, X-ray skull are diagnostic. Treatment is surgical decompression by craniotomy through subfrontal approach or trans-sphenoidal approach. Deep external radiotherapy and steroids are also used. 3. Basophil adenomas are usually small. They secrete ACTH and presents as Cushing's disease with all its features. 4. Prolactin-secreting adenomas causes infeility, amenorrhoea and galactorrhoea. It can be of two types Microprolactinomas - < 10mm Macroprolactinoma - > 10 mm Classification II Hypersecreting Hyposecreting by compression and atrophy Classification III Micronodular: Tumour size less than 10 mm Macronodular: Tumour size more than 10 mm Stages Stage of intrasellar development Stage of suprasellar extension Stage of massive intracranial extension Ref : SRB's Manual of Surgery 5th edition Pgno : 1105