CD59 deficiency leads to:
High-Yield Explanation
Ref. Robbins Pathology. 9th edition. Page. 642
PNH :
Defect in GPI linked proteins - CD55 and CD 59
Mutation in PIGA gene
Intravascular hemolysis
Triad – IV hemolysis, Thrombosis, Pancytopenia
Can result in AML
Diagnostic methods
HAM test – no more used
Gel card test
Flow cytometry – IOC
Best – FLAER (Fluorescent Aerolysin test)