Beta-naphthyl amine dyes predisposes to:September 2005

Ans. A: Urinary bladder CarcinomaRehn in 1895 first implicated aniline dyes as cocarcinogenic agent for bladder malignancy.Other aromatic amines like 2-naphthylamine, benzidine, xenylamine, 4-aminobiphenyl, 4-nitrobiphenyl, combustion gases, soot and coal, acrolein are also cocarcinogenic.It has been estimated that occupational exposure accounts for involving 20% of bladder cancer.People exposed to these dyes are workers of rubber, dye, cable, petroleum industries, textile industries,leather industries, beautician, painter.The latency period is long varying between 18 to 40 years