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Pediatrics General d156cc28

True statement about inheritance of an X linked recessive trait is –

A
50% of boys of carrier mother are affected
B
50% of girls of diseased father arecarrier
C
Father transmits disease to the son
D
Mother transmits the disease to the daughter
High-Yield Explanation
Features of X-linked disorders Except for a few conditions, all X-linked disorders are X-linked recessive. A male has only one X-chromosome, the male with an affected gene on X-chromosome will always manifest the disease. On the other hand, the female has 2 X-chromosomes, the heterozygous female will be a carrier because of the expression of a normal allele on the other X-chromosome. Note - Female with Turner syndrome (only one 'X' chromosome) can manifest X-linked recessive disorders. 50% boys of the carrier mother will be affected. All daughters of an affected father will become a carrier, i.e. affected father will transmit the defective X-chromosome to all the daughters. Father will not transmit the disease to son as boys do not inherit X-chromosome from father.

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