Active replication in Hepatitis B infection is indicated by?

o HBeAg is an indicator of active intrahepatic replication and high infectivity. o It is a qualitative marker of HBV replication. Serologic and virologic markers of HBV infection 1. HBs Ag o First virological marker detectable in the serum o HBsAg presence precedes elevations of serum aminotrans ferase activity and onset of clinical illness, o HBsAg become undetectable 1-2 months after the onset of jaundice and rarely persists beyond 6 months, o In chronic HBV infection, HBsAg remains detectable beyond 6 months. 2. HRcAg o It is not demonstrable in the circulation because it is enclosed within the HBs Ag coat, o HBc Ag remain in the hepatocyte, where it can readily be detectable by immunohistochemical staining. 3. HBeAg o HBe Ag appears concurrently with or shortly after HBs Ag. o HBe Ag is an indicator of active intrahepatic replication and high infectivity. o It is a qualitative marker of HBV replication. o HBs Ag carrier mothers who are HBe Ag positive almost invariably (> 90%) transmit hepatasis B infection To their offspring, where as HBs Ag carrier mothers with an HBe rarely (10 to 15%) infect their offspring. o HBe testing is indicated primarily during follow up of chronic infection. 4. And HBc Ag o Appears w ithin the first 1 to 2 weeks after the appearance of HBs Ag. o In acute or recent infection IgM an HBc is detected. o IgG an HBc indicates remote infection. 5. An HBsAg o It becomes detectable in blood when HBs Ag disappears, o An HBs Ag is protective  antibody. o It is the only serological marker, present after immunization. 6. An HBeAg o Disappearance of HBe Ag is followed by the appearance of anHBeAg. o Its presence indicates low infectivity' and virus replication. 7. HBVDNA o it is the quantitative marker of virus replication