A 19-year-old college student develops a severe sore throat, cervical lymphadenopathy, and atypical lymphocytes on blood film. A heterophil antibody test is positive. For the above patient with a hematologic abnormality, select the most likely diagnosis
High-Yield Explanation
Heterophil antibodies react against sheep red cells and are not absorbed out by the guinea pig kidney. They are positive in patients with infectious mononucleosis. In 90% of cases, liver enzymes are elevated. Examination of the blood film reveals a lymphocytosis with atypical lymphocytes.