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Social & Preventive Medicine General d071a602

Which of the following is not a type of Vaccine derived polio virus?

A
cVDPV
B
iVDPV
C
mVDPV
D
aVDPV
High-Yield Explanation
Vaccine derived polio virus (VDPV) Properties of VDPV: – Occurs due to Sabin (OPV) vaccine: P3 (60% of all cases) > P2 > P1 – Clinical presentation indistinguishable from Wild polio virus (WPV) – cVDPV present similar public health threat like WPV – iVDPV prolonged infection may transmit virus to others Incidence of VDPV: 4 cases per million birth cohort per year Types of VDPV: – cVDPV: Person-to-person transmission in community – iVDPV: Isolates from immunodeficient persons – aVDPV: Ambiguous from healthy person or sewage isolates Key risk factors for cVDPV emergence: – Development of immunity gaps (due to low OPV coverage) – Prior elimination of WPV types – Low routine immunization coverage with trivalent OPV – Insensitive AFP surveillance Diagnosis: – Real time Reverse transcription – PCR nucleic acid amplification

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