Smita is a case of infertility. What is the right time in her menstrual cycle to do endometrial biopsy:

Endometrial biopsy should be taken in premenstrual phase 1 – 2 days before the onset of menstruation Endometrial Biopsy • OPD procedure for hormonal evaluation in case of infertility / DUB/TB. • Usually performed in pre–menstrual phase from the lateral wall of vagina. • Interpretation: Presence of secretory endometrium → Progesterone phase (cycles has been ovulatory) Presence of proliferative endometrium → Estrogen phase (cycles has been anovulatory) • Luteal phase defect can also be diagnosed by endometrial biopsy (which shows a lag of 2 – 3 days between calendar and histological dating of specimen. Note: For the diagnosis of luteal phase defect endometrial biopsy is done between day 24-26 of the menstrual cycle or 2 to 4 days before anticipated menstruation. • Endometrial biopsy is contraindicated in suspected malignancy/sepsis. • 1st sign of ovulation on endometrial biopsy is parabasal vacuolation