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Surgery General d00a3927

VIPoma is associated with which syndrome:

A
Zollinger Ellison
B
Verner Morrison
C
Carcinoid syndrome
D
Cushing's syndrome
High-Yield Explanation
VIPomas are endocrine tumors that secrete excessive amounts of vasoactive intestinal peptide (VIP), Excessive VIP causes a distinct syndrome characterized by large-volume diarrhea, hypokalemia, and dehydration. This syndrome also is called Verner-Morrison syndrome, pancreatic cholera, and WDHA syndrome for watery diarrhea, hypokalemia, and achlorhydria. The principal symptoms are large-volume diarrhea (100%) severe enough to cause hypokalemia (80-100%), dehydration (83%), hypochlorhydria (54-76%), and flushing (20%). In adults 80-90% of VlPomas are pancreatic in location, with the rest due to VIP-secreting pheochromocytomas, intestinal carcinoids, and rarely ganglioneuromas.

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