The following statements regarding tissue plasminogen activator are true, except:

Tissue plasminogen activator (alteplase) is produced by recombinant DNA technology. It is a poor plasminogen activator in the absence of fibrin. Its specificity for fibrin limits systemic formation of plasminand induction of systemic lytic state. It is given as intravenous bolus for coronary thrombolysis during treatment of myocardial infarction.