Uremia occurs when total GFR is reduced by ?

Ans. is 'a' i.e., 25%First read about two impoant and interrelated terms :-Azotemia --> Elevation of blood urea nitrogen (BUN) and creatinine levels without clinical signs and symptoms. Uremia --> Elevation of BUN and creatinine levels with clinical signs and symptoms, i.e. uremia =Azotemia + Clinical signs and symptoms.Coming back to the question.The evolution from Normal renal function to symptomatic chronic renal failure progresses through four stages ?Diminished renal reserveo The GFR is about 50% of normalo BUN and creatinine values are normal and the patient is asymptomatic.o However, they are more susceptible to developing azotemia with an additional renal insult.Renal insufficiencyo The GFR is 20% to 50% of normal.o Azotemia appears, usually associated with anemia and hypeension.o Sudden stress may precipitate uremia.Renal failureo The GFR is less than 20% to 25% of normal.o The kidney cannot regulate volume and solute composition, and patients develop ove uremia.End-stage renal diseaseo The GRF is less than 5%.o This is the terminal stage of uremia.