Pathologic features of brain in AIDS are all, except

Unlike most other viral encephalitides, HIV does not seem to infect neurons and perivasculitis is conspicuously absent" - Anderson pathology 10th/e p. 2728 "Characteristic multinuclear Giant cells of macrophage origin are seen in deep white matter of frontal and temporal lobes particularly in perivascular location" - Anderson p. 10th /e . These lines from Anderson have clarified any doubts regarding this question. The answer is fairly obvious. Other characteristic pathologic feature of CNS in AIDS are : Diffitse and focal spongiform changes Vascular myelopathy of post column of spinal cord Major cells affected are macrophages and monocytes Most characteristic finding is chronic inflammatory reaction with widely distributed infiltrates of microglial nodules.