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Pathology Renal carcinoma cf2d3b75

Which of the following genes is associated with Xp11 translocation carcinoma variant of renal cell carcinoma?

A
VHL
B
TFE3
C
MET
D
TSC1
High-Yield Explanation
Xp11 translocation Carcinoma: It is a rare genetically distinct subtype of renal cell carcinoma. More common in children. TFE3 gene located at Xp11.2 locus is involved The neoplastic cells consist of clear cytoplasm with a papillary architecture. VHL is associated with clear cell RCC. MET is associated with hereditary papillary RCC. TSC1 is associated with renal angiomyolipoma.

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