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Medicine Hereditary Hyperbilirubinemia & Jaundice cf1a89ec

All of the following are associated with unconjugated bilirubin except?

A
Cryoglobulinemia associated with hepatitis C
B
History of gout
C
Spherocytes in peripheral smear
D
Gall stone
High-Yield Explanation
Cryoglobulinemia associated with hepatitis C doesn't cause rise in unconjugated bilirubin, instead it is associated with conjugated variety of bilirubin. =Gall stones such as pigmentary stones are associated with hemolysis which increases unconjugated bilirubin =Spherocytes also cause hemolysis =Gout patients on treatment with probenecid causes decrease in uptake of bilirubin resulting in elevated unconjugated bilirubin levels. Bilirubin metabolism

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