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Biochemistry Vitamins and Minerals ced20ce9

A chronic alcoholic have low energy production because of Thiamine deficiency as it is:

A
Acting as a cofactor for alpha ketoglutarate dehydrogenase and pyruvate dehydrogenase
B
Acting as cofactor for transketolase in pentose phosphate pathway
C
Interferes with energy production from amino acids
D
Act as cofactor for oxidation reduction
High-Yield Explanation
Ans. A. Acting as cofactor for alpha ketoglutarate Dehydrogenase and pyruvate dehydrogenase(Ref. Harper 31/e page 151-155)Alpha ketoglutarate dehydrogenase (TCA cycle) and PDH (link between aerobic glycolysis and TCA) require Thiamine, hence affect energy production, in alcoholic patients thiamin deficiency is present.

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