Pathology Cellular Pathology ce7318a3 Earliest change in cell death is? A Karyolysis B Loss of plasma membrane C Cell swelling D Karyorrhexis High-Yield Explanation Ans. (c) Cell swelling(Ref: Robbins 9th/pg 46; 8th/pg 12)Earliest change in any form of cell injury is cellular swelling due to accumulation of water intracellularly.