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Gynaecology & Obstetrics Sexuality and intersexuality ce5996ef

Most common cause aof ambigious genitalia in a female child is :

A
Placenta steriod sulfatase deficiency
B
Fetal aromatase deficiency
C
Wnt4 mutation
D
Congenital adrenal hyperplasia
High-Yield Explanation
CONGENITAL ADRENAL HYPERPLASIA Clinical presentation: Ambiguity of sex detected at bih are due to androgenital syndrome unless proved otherwise. Hirsutism and amenorrhea may be presenting features around pubey in milder form. Diagnosis at bih An enlarged clitoris Presence of penile urethra or hypospadias Hyponatremia,hypokalemia and hypotension Fusion of labia minora Ref: D.C.DUTTA'S TEXTBOOK OF GYNAECOLOGY,6th edition; Pg no:440 other causes include female psuedohermaphroditism,mixed gonadal dysgenesis, male psudeohermaphroditism and rarely true hermaphroditism page 54 ,16th edition shaw's textbook of gynaecology

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