A 10-month-old patient with recurrent pyogenic infections, eczema, and severe bleeding (thrombocytopenia) is diagnosed with Wiskott-Aldrich syndrome. This immune disorder is usually associated with which of the following?

Immunodeficiency disorders can be categorized according to whether the defect primarily involves humoral immunity (bone marrow derived, or B lymphocytes) or cellular immunity (thymus derived, or T lymphocytes) or both. Swiss-type hypogammaglobulinemia, ataxia-telangiectasia, the Wiskott-Aldrich syndrome, and severe combined immunodeficiency disorders all involve defective B-cell and T-cell function. Infantile X-linked agammaglobulinemia is caused chiefly by deficient B-cell activity, whereas thymic hypoplasia is mainly a T-cell immunodeficiency disorder.Wiskott-Aldrich syndrome, an X- linked defect, is associated with reduced IgM levels and variable cellular-mediated immunity.