Displacement of a protein bound drug-

Ans. is 'a' i.e., T Drug plasma level One drug can bind to many sites on the albumin molecules. o Conversely, more than one drug can bind to the same site. o This can give rise to displacement interactions among drugs bound to the same sites. o Drug bound with higher affinity will displace that bound with lower affinity. The concentration of free form (plasma level) will increase. o However this is often transient because the displaced drug will diffuse into the tissues as well as get metabolized or excreted. o The new steady state free drug concentration is only marginally higher unless the displacement extends to tissue binding or there is concurrent inhibition of metabolism and excretion. The overall impact of many displacement interactions is minimal, clinical significance being attained only in case of highly bound drugs with limited volume of distribution and where interaction is more complex.