A 38-year-old Primigravida who is pregnant after IVF , has a sonogram performed that shows Nuchal translucency of 5 mm at 12wks 4 days gestation. Which of the following is the only true statement?

Nuchal translucency measured between 10 and 13 weeks is a useful marker for increased risk of chromosome abnormalities such as Down syndrome (not neural tube defects). The larger the nuchal translucency, the greater the risk of other adverse pregnancy outcomes, including fetal demise, cardiac abnormalities, and other genetic syndromes, even if the karyotype is normal. The nuchal translucency will almost always disappear by 15 weeks Increased nuchal translucency in aneuploid fetuses most likely indicates Down syndrome, followed by trisomy 18 and then Turner syndrome.