Methacholine is a:(AIIMS May 2015, May 2014)

Ans. b. M2 receptor agonist (Ref: KDT 7/e p101; Katzung p100)Methacholine is a M2 receptor agonist. M1M2M3Location and functionAutonomic ganglia:Depolarization (late EPSP)Gastric glands: Histamine release and acid secretionQCNS: Learning, memory and motor functionsQSA node: Hyperpolarization, | rate of impulse generationQAV node: | velocity of conductionAtrium: Shortening of APD, | contractilityQVentricle: | contractility (slight as receptors are sparse)Cholinergic nerve endings: | ACh releaseQCNS: Tremors, analgesiaVisceral smooth muscles: ContractionQVisceral smooth muscles: ContractionQIris: Constriction of pupilQ Ciliary muscles: ContractionQExocrine glands:SecretionQVascular endothelium:Release of NO - VasodilationQNatureGq-protein coupledGi/Go protein coupledGq-protein coupledTransducer mechanismIP3/DAG - | cytosolic calcium; | PLA2 - PG synthesisK+ channel opening, | cAMPIP3/DAG -| cytosolic calcium;|PLA2 - PG synthesisAgonists(Relatively selective)Oxotremorine, MCN- 343AMethacholineQBethanecholAntagonists(Relatively selective)Pirenzepine,TelenzepineMethoctramine, TripitramineDarifenacin, Solefenacin