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Microbiology Bacteriology cc24b057

True about corynebacterium diphtheria is all except

A
Diptheriae invasion is not seen
B
Eleks test is done for toxigenicity
C
Metachromatic granules are seen
D
Toxigenicity is mediated by chromosomal change
High-Yield Explanation
Toxigenicity of the diphtheria bacilli depends on the presence in it of corynephages which acts as the genetic determinant controlling toxin production. The diphtheria toxin acts by inhibiting protein synthesis. Specifically, a fragment B heparin binding and fragment A inhibits polypeptide chain elongation in the presence of nicotinamide adenine dinucleotide by inactivating the elongation factor EF-2. Reference: Textbook of Microbiology; Anathanarayan and panicker's; 10th edition; Page no: 240

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