Which of the following type of IL is known to cause fever?

IL1 and TNF alpha are endogenous pyrogens that are capable of stimulating fever, promoting local inflammatory reactions and synthesis of acute phase proteins. IL1, IL 6, TNF alpha are proinflammatory cytokines sometimes referred to as acute phase cytokines. IL 1 is produced mainly by activated macrophages, neutrophils, epithelial and endothelial cells. Two forms of IL 1 are IL 1alpha and IL 1 beta. IL 1a is cell associated whereas IL 1beta is the predominant form and is secreted by macrophages. TNF alpha acts on the hypothalamus to induce fever, can cause systemic metabolic changes, weight loss and loss of appetite, and enhance production of IL1, IL6, and chemokines and it promotes acute phase protein synthesis by the liver. At high concentrations, it elicits all of the functions leading to a septic shock. Ref: Principles of Cancer Biotherapy edited by Robe K. Oldham, page 61, Medical Microbiology,with STUDENT CONSULT Online Access,7: Medical Microbiology By Patrick R. Murray, PAGE 57.