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Pathology NEET 2019 cad5a635

MRP 2 and conjugated hyperbilirubinemia associated with which of the following?

A
Criggler Najjar syndrome type I
B
Criggler Najjar syndrome type II
C
Dubin Johnson syndrome
D
Rotor syndrome
High-Yield Explanation
Dubin-Johnson Syndrome:- Defect in canalicular protein called MRP2 leading to increase in conjugated bilirubin (CB). Criggler Najjar Syndrome type I and type II has decrease activity of UDP-glucuronodyltransferases leading to increase unconjugated bilirubin (UCB) which enters CNS and can cause kernicterus.

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