All are true about estrogen, EXCEPT:

They promote the development of female secondary sexual characteristics, such as breast development. So it is not used in treatment of gynaecomastia. Estrogen and other hormones are given to postmenopausal women as a pa of hormone replacement therapy (H) in order to prevent osteoporosis as well as treat the symptoms of menopause. About 80% of breast cancers rely on supplies of the hormone estrogen to grow: they are known as hormone-sensitive or hormone-receptor-positive cancers. Suppression of production of estrogen in the body is a treatment for these cancers. Estrogens cause intrahepatic cholestasis by altering the composition of the lipid membrane and inhibiting the rate of secretion of bile into the canaliculi.