AML transformation common in

Aplastic anemia to AML Aplastic anemia (AA) is a clinical syndrome of peripheral blood pancytopenia and a hypocellular bone marrow. Immunosuppressive therapy is a key treatment strategy for AA. Genomic instability in AA does not appear to be a rare event. AA evolves into acute myeloid leukemia (AML) in 5-15% of all cases Ref Davidson 23rd edition pg 969