Pharmacology C.V.S c9c94e16 Sodium-nitroprusside acts by activation of: A Guanylate cyclase B K+ channels C Ca++ channels D Cyclic AMP High-Yield Explanation Ans. (A) Guanylate cyclase(Ref: KDT 8th/e p613)Nitroprusside generates NO that relaxes vascular smooth muscles by activating guanylate cyclase.